Novel Oral Polio Virus Type 2 Vaccine

Novel Oral Polio Virus Type 2 Vaccine

No new (2023) Wild Polio cases reported this week.  We are now 7 weeks since the most recent reported Wild Polio Case – on 2/20/23 in Pakistan. 

What is that Polio Picture? Novel Oral Polio Virus Type 2 Vaccine

In 2011, a major endeavor was launched to develop a more genetically stable version of the monovalent oral Polio vaccine type 2 (mOPV2) to more sustainably stop outbreaks of type 2 variant poliovirus.

Fast forward to today, and close to 600 million doses of the novel oral polio vaccine type 2 (nOPV2) have been used across 28 countries in outbreak response. More than two thirds of all countries that have used nOPV2 for outbreak response did not report continued transmission following two vaccination campaigns. In some areas with persistent transmission, we’ve seen interruption [of transmission] after a third round. There are, however, a few geographic settings where the virus persists despite multiple campaigns, and these are the areas where we need to focus more on reaching missed children with the vaccine, to stamp out the remaining reservoirs of transmission.

Overall field effectiveness of nOPV2 in stopping paralytic outbreaks seems to be comparable with Sabin mOPV2, which is in line with clinical study findings. Most importantly, with lower risk of seeding new outbreaks compared to the Sabin mOPV2 experience as noted by field data so far, nOPV2 continues to demonstrate that it is an excellent tool to more sustainably stop outbreaks. GPEI – Ananda S. Bandyopadhyay (Bill & Melinda Gates Foundation)

World Immunization Week – April 24-30, 2023

A Win Against Polio is a Win for Global Health!

One new (2023) Wild Polio case reported this week.  We are now 4 weeks since the most recent reported Wild Polio Case – on 2/20/22 in Pakistan.

2023 Circulating Vaccine Derived Polio Cases – 47  Benin – 2, Central African Republic – 5, Chad – 5, DR Congo – 23, Indonesia – 3, Israel – 1, Madagascar – 5, Mozambique – 1, Nigeria – 1, Somalia – 1.

New Polio Cases & Samples This Week – Benin – 1 cVDPV2 Case, Burundi – 3 cVDPV2 Samples, DR Congo – 6 cVDPV2 Cases + 1 cVDPV1 Case + 1 cVDPV2 Sample, Somalia – 1 cVDPV2 Sample

2022 Circulating Vaccine Derived Polio Case Total – 843   Afghanistan – 43, Algeria – 3, Benin – 11 (3 in 2021), Burundi – 1, Cameroon – 3 (3 in 2021), Central African Republic – 5, Chad -44 (0 in 2021), DR Congo – 476 (28 in 2021), Republic of Congo – 1, Eritrea – 1, Ethiopia – 1, Ghana – 3, Indonesia – 1, Israel – 1, Madagascar – 14 (13 in 2021), Malawi – 4, Mali – 2, Mozambique – 21 (2 in 2021), Niger – 15 (18 in 2021), Nigeria – 48 (415 in 2021), Pakistan – 8, Somalia – 5 (1 in 2021), Sudan – 1, Togo – 2, United States – 1, Yemen – 162 (69 in 2021).

2021 Circulating Vaccine Derived Polio Cases -689 in 22 Countries.  

2020 Circulating Vaccine Derived Polio Cases – 1,113 in 26 countries in 2020.

Quote of the Day

“The road to success is always under construction.

— Lily Tomlin, Actress 

The Final Two Polio Endemic Countries:

Pakistan

 

 

as of 4/14/2023

0 new Polio cases reported this week. The most recent cases had an onset of paralysis on 2/20/23.
0 WPV1 and 0 CVDPV2-Positive Environmental Samples were reported this week in Afghanistan.
1 Wild Polio cases – 2023
20 Wild Polio cases – 2022
1 Wild Polio case – 2021
84 Wild Polio cases – 2020

Afghanistan

 

 

as of 4/14/2023

0 new Polio cases reported this week. The most recent cases had an onset of paralysis on 8/29/22.
0 WPV1 and 0 CVDPV2-Positive Environmental Samples were reported this week in Afghanistan.
0 Wild Polio cases – 2023
2 Wild Polio case – 2022
4 Wild Polio cases – 2021
56 Wild Polio cases – 2020

Our Goal is Global Polio Eradication!!

Terry Ziegler, Endowment/Major Gifts Adviser Rotary Region 36